Molecules for treating diseases related to ErbB / ErbB ligands and methods of using the molecules

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专利权人:

イェダ リサーチ アンド デベロップメント カンパニー リミテッド

发明人:

リンゼン， モシト,ヤーデン， ヨセフ,リンゼン, モシト,ヤーデン, ヨセフ

申请号：

JP2013505597

公开号：

JP5858984B2

申请日:

2011.03.22

申请国别(地区):

JP

年份:

2016

代理人:

摘要：

A method of selecting a target for treatment of a hyperproliferative disease in a subject in need thereof is disclosed. The method comprising analyzing an amount and/or activity of at least one ErbB ligand in a biological sample from the subject, wherein an ErbB ligand which shows an up-regulated amount and/or activity compared to a non-hyperproliferative cell or tissue above a predetermined level is selected as a target for treatment of the hyperproliferative disease. Methods of treating hyperproliferative diseases, monoclonal antibodies and pharmaceutical compositions are also disclosed.

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