The present invention provides products, systems, and methods for the unique identification of individual drug dosage form units. The invention includes: random integrated optical identification marking of an individual drug unit； a lack of direct surface-to-surface contact between a marking instrument and the drug unit, i.e., deposition of a mark； drug unit image data based on the identification mark； a secondary product identifier associated with the individual drug unit； and comparing the marked drug unit to drug unit image data.
