N-Алкил-тропины и N-алкил-нортропины с н-холиноблокирующей, нейропротекторной, противопаркинсонической, противоэпилептической, анальгезирующей, антидепрессивной и антиаддиктивной активностью
Гмиро Валерий Евгеньевич (RU),Шабанов Петр Дмитриевич (RU),Сердюк Сергей Евгеньевич (RU)
申请号：
RU2014144479
公开号：
RU2014144479A
申请日:
2014.11.05
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. The use of N-alkyl derivatives of tropine and nortropina general formula (1) where R - H, Me, R- alkyl of the general formula CH, X- anion of an acid, n = 3-16, for the treatment of ischemic CNS and neurodegenerative diseases, epilepsy, Parkinsonism , Alzheimers disease, Huntingtons chorea, depression, pain, addiktsii.2. Compounds of general formula (I) are obtained by alkylation of tropine (II, R = Me) or nortropina (II, R = H) with an appropriate alkylating agent RX according to the following scheme: wherein R - H, Me, R - alkyl group of the formula CH, X - kisloty.3 anion. Use of N-alkyl derivatives of tropine and nortropina general formula (I) in combination with antiepileptic treatment for epilepsii.4. Use of N-alkyl derivatives of tropine and nortropina general formula (I) in combination with L-dopa for the treatment parkinsonizma.5. Use of N-alkyl derivatives of tropine and nortropina general formula (I) in combination with a narcotic and non-narcotic analgesics for the treatment boli.6. A method of treating ischemic and neurodegenerative diseases of the CNS, epilepsy, Parkinsonism, Alzheimers disease, Huntingtons chorea, depression, pain and addiction, which is a parenteral (subcutaneous, intramuscular, intravenous) administration of effective amounts of N-alkyl derivatives of tropine and nortropina general formula (I). 7. A method of treating ischemic and neurodegenerative diseases of the CNS, epilepsy, Parkinsonism, Alzheimers disease, chorea Gettingtona, depression, pain and addiction, which comprises oral administration of effective amounts of N-alkyl derivatives of tropine and nortropina general formula (I).1. Применение N-алкилпроизводных тропина и нортропина общей формулы (1)где R - H, Me, R1 - алкил общей формулы CnH2n+1, X- - анион кислоты, n=3-16,для лечения ишемических и нейродегенеративных заболеваний ЦНС, эпилепсии, паркинсонизма, болезни Альцгеймера, хореи Гентингтона, депрессии, боли, аддикции.2. Соединения общей формулы (I) получаются путе
