#$%^&*AU2016253580A120161124.pdf#####ABSTRACT A neele device for the delivery ofithepeutic mteriaid into tissue comprising a cneion to a pressure generation element, a lumen adapted Ior the passage ofLa therpigc material, and a needle barrel wherein each needle barrel comprises an opening adapted to control and deliver a pressure transmitted from the presse generIation element into atisse to cause anL inches in the permeability of a cell mebrane to the therapeutic material.