Michael Anthony Hollingsworth,Prakash Radhakrishnan
申请号：
US14902473
公开号：
US20160376376A1
申请日:
2014.06.24
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present disclosure relates to a method of inhibiting tumor growth. More specifically, the present disclosure relates to the use of monoclonal antibodies for targeting truncated O-glycans on glycoproteins to inhibit activation of pro-survival ceil signaling pathways, to inhibit tumor growth. For example, monoclonal antibody AR9.6 may be used to target truncated O-glycans on the MUC16 glycoprotein, thereby inhibiting the phosphatidyiinositol 3-kinase/Akt (Pi3K/Akt) signaling pathway.
