Described embodiments are directed toward centrally-opening leaflet prostheticvalve devices having a leaflet frame coaxially disposed within a body frame,as well asmethods of making the valve devices. A method of making a multi-frameprosthetic valve(100) comprises: providing a body frame (120) defining a generally tubularshapedefining a body frame lumen； providing a leaflet frame (130) having agenerally annularshape defining a plurality of U-shaped portions each defining a base and aplurality ofposts； providing a film； forming a first layer of the film into a tubularform； coaxiallyplacing the leaflet frame over the tubular form of the first layer of film；wrapping the filmaround the leaflet frame and the tubular form of the first layer of film, thefilm extendingacross each of the U-shaped portions so as to define a leaflet (140) therein；bonding thefirst layer and the second layer to each other and the leaflet frame； clampingthe leafletsdisposed in the U-shaped portions to enclose the leaflets； forming a thirdlayer of the filmover the leaflet frame； placing the body frame over the third layer of thefilm and over theleaflet frame such that the leaflet frame is coaxially disposed within thebody framelumen forming a fourth layer of the film over the body frame and the thirdlayer of thefilm； and bonding the third layer and the fourth layer to each other and thebody frame.
