A seat protection pad to protect a seat against spilled liquids and other bodily fluids including human and animal fluids, including a base pad having a first side and a second side and a front portion, a mid-section portion and a rear portion, wherein the base pad includes a base pad opening located between the mid-section portion and the front portion, an upper pad having a first side and a second side and a front end and a rear end, wherein the upper pad is attached to the first side of the base pad at a location adjacent to the front portion of the base pad such that the second side of the upper pad is located adjacent to the first side of the base pad, an upper pad opening located between the front end of the upper pad and the front portion of the base pad such that the upper pad opening is aligned with the base pad opening to allow a seat belt buckle to be inserted through the base pad opening and the upper pad opening, a plurality of adhesive strips located on the second side of the base pad, wherein a first one of the plurality of adhesive strips is attached adjacent to the rear portion of the base pad, a second one of the plurality of adhesive strips is attached adjacent to the mid-section portion of the base pad and a third one of the plurality of adhesive strips is attached adjacent to the front portion of the base pad, and a plurality of stitches located on each of the plurality of adhesive strips for securing the plurality of adhesive strips to the base pad.