MAGUIRE, MARTIN P.,RIOUX, ELISE,LEIGHTON, HARRY J.,MAGUIRE MARTIN P,RIOUX ELISE,LEIGHTON HARRY J
申请号：
ES08768636
公开号：
ES2498047T3
申请日:
2008.06.19
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A pharmaceutical composition comprising a compound having the formula: ** Formula ** or a pharmaceutically acceptable addition salt thereof, or any enantiomer or diastereomer thereof, in which: - each a, b, c, d, e and f is, independently, -CH2-, -O-, -S- or a single bond, - each R11, R12, R13, R41, R15, R16 and R17 is, independently: H, lower alkyl, lower alkyl substituted with - CO2 (lower alkyl), lower alkyl substituted with -CO2 (lower alkoxyalkyl), lower alkyl substituted with fluorine or chlorine, lower alkoxyalkyl, lower alkoxyalkyl substituted with -CO2 (lower alkyl), lower alkoxyalkyl substituted with -CO2 (alkoxyalkyl lower), lower alkoxyalkyl substituted with fluorine or chlorine or CO2R10, - each R10 is, independently, lower alkyl or lower alkoxyalkyl, - R18 is H, CN or CO2R10, and - R19 is H, g is a single bond and R20 it's H； wherein at least one of R11, R12, R13, R14, R15, R16, R17 and R18 is CO2R10, lower alkyl substituted with-CO2 (lower alkyl), lower alkyl substituted with -CO2 (lower alkoxyalkyl), substituted lower alkoxyalkyl with - CO2 (lower alkyl), or lower alkoxyalkyl substituted with -CO2 (lower alkoxyalkyl)； wherein said lower alkyl is C1-7 alkyl and said lower alkoxyalkyl is C1-7 alkyl substituted with a C1-7 alkoxy group.Una composición farmacéutica que comprende un compuesto que tiene la fórmula:**Fórmula** o una sal de adición farmacéuticamente aceptable del mismo, o cualquier enantiómero o diastereómero del mismo, en la que: - cada a, b, c, d, e y f es, de forma independiente, -CH2-, -O-, -S- o un enlace sencillo, - cada R11, R12, R13, R41, R15, R16 y R17 es, de forma independiente: H, alquilo inferior, alquilo inferior sustituido con - CO2(alquilo inferior), alquilo inferior sustituido con -CO2(alcoxialquilo inferior), alquilo inferior sustituido con flúor o cloro, alcoxialquilo inferior, alcoxialquilo inferior sustituido con -CO2(alquilo inferior), alcoxialquilo inferior sustituido con -CO2(alcoxialquilo inferior), alcoxialquilo infe
