A process for removing or treating harmful biological and organic substances within an enclosure includes heating the ambient air within the enclosed area to a predetermined temperature over time to cause harmful biological or organic substances to be destroyed or migrate into the ambient air. Temperature and pressure levels are monitored through the treatment process. Contaminated objects or areas may be subjected to biocides, irradiation, or even freezing as part of the treatment process. The air removed from the enclosure is preferably passed through an incinerator, a filter or an irradiation device and the heated air is re-circulated to enhance efficiency.