Connectors for respiratory assistance systems are disclosed. The connectors include an inspiratory conduit port, an expiratory conduit port, a first interface port, a second interface port, and a body or body portion formed between the inspiratory conduit port, the expiratory conduit port and the first and second interface ports, the body or body portion defining an interior cavity that fluidly couples, at least in part, the inspiratory conduit port and the expiratory conduit port to the first and second interface ports. The first and second interface ports are each fluidly couplable to a patient interface. Preferably, the first interface port is adapted to be coupled to an adult patient interface and the second interface port is adapted to be coupled to a pediatric or neonatal patient interface.