KIM, Sung Wuk,JUN, Sung Soo,PARK, Seung Kook,KIM, Song Young,KIM, Eun Sun,JEONG, Jae Kap,KIM, Ha Na,SONG, Yeon Jung
申请号：
ES11851725
公开号：
ES2626418T3
申请日:
2011.12.21
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A modified tumor necrosis factor-1 receptor polypeptide comprising an amino acid sequence selected from the group consisting of: an amino acid sequence comprising an amino acid modification selected from the group consisting of L68V / S92I / H95F / R97P / H98A , L68V / S92M / H95F / R97P / H98A, L68V / S92H / H95F / R97P / H98A, L68V / S92I / H95F / R97P / H98G and L68V / S92M / H95F / R97P / H98G consisting of an amino acid sequence (TNFRI171) at amino acids 41-211 of an amino acid sequence of a wild-type polypeptide of the tumor necrosis factor-1 receptor represented by SEQ ID NO: 1； an amino acid sequence comprising an amino acid modification selected from the group consisting of L68V / S92I / H95F / R97P / H98A, L68V / S92M / H95F / R97P / H98A, L68V / S92H / H95F / R97P / H98A, L68V / S92I / H95F / R97P / H98G and L68V / S92M / H95F / R97P / H98G in an amino acid sequence (TNFRI126) consisting of amino acids 41-166 of an amino acid sequence of a wild-type necrosis factor receptor-1 polypeptide tumor represented by SEQ ID NO: 1； and an amino acid sequence comprising an amino acid modification selected from the group consisting of L68V / S92I / H95F / R97P / H98A, L68V / S92M / H95F / R97P / H98A, L68V / S92H / H95F / R97P / H98A, L68V / S92I / H95F / R97P / H98G and L68V / S92M / H95F / R97P / H98G in an amino acid sequence (TNFRI105) consisting of amino acids 41-145 of an amino acid sequence of a wild type factor-1 receptor polypeptide of tumor necrosis represented by SEQ ID NO: 1.Un polipéptido modificado del receptor-1 del factor de necrosis tumoral que comprende una secuencia de aminoácidos seleccionada del grupo que consiste en: una secuencia de aminoácidos que comprende una modificación de aminoácidos seleccionada del grupo que consiste en L68V/S92I/H95F/R97P/H98A, L68V/S92M/H95F/R97P/H98A, L68V/S92H/H95F/R97P/H98A, L68V/S92I/H95F/R97P/H98G y L68V/S92M/H95F/R97P/H98G en una secuencia de aminoácidos (TNFRI171) que consiste en los aminoácidos 41-211 de una s
