PROCESS FOR PREPARING SPRAY DRIED SOLID DISPERSIONS OF (S)-N-(3-(6-ISOPROPOXYPYRIDIN-3-YL)-1H-INDAZOL-5-YL)-1-(2-(4-(4-(1-METHYL-1H-1,2,4-TRIAZOL-3-YL)PHENYL)-3,6-DIHYDROPYRIDIN-1(2H)-YL)-2-OXOETHYL)-3-(METHYLTHIO)PYRROLIDINE-3-CARBOXAMIDE FOR PHARMACEUTICAL PREPARATIONS

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专利权人:

Merck Sharp & Dohme Corp.;Yung-Chi LEE;Dan ZHANG

发明人:

Yung-Chi Lee,Dan Zhang

申请号：

US15756630

公开号：

US20180250232A1

申请日:

2016.08.29

申请国别(地区):

US

年份:

2018

代理人:

摘要：

A process for preparing spray dried solid dispersions of (S)—N-(3-(6-isopropoxypyridin-3-yl)-1H4ndazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide amorphous free base and hypromellose acetate succinate for pharmaceutical preparations including pharmaceutical capsule preparations.

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