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FLUOROERGOLINE DERIVATIVES AND USES THEREOF
专利权人:
MAP PHARMACEUTICALS; INC.
发明人:
Thomas Armer,Shashidhar Kori,Libo Wu
申请号:
US14134120
公开号:
US20140179706A1
申请日:
2013.12.19
申请国别(地区):
US
年份:
2014
代理人:
摘要:
Provided herein are novel fluoroergoline derivatives and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1D and/or the 5-HT1B receptor, without agonizing the 5-HT2B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the adrenergic alpha2A and/or the alpha2B receptors using the compounds and compositions disclosed herein.
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