In some embodiments, a tissue removal system may comprise a handheld housing and a tissue collection chamber coupled to a distal portion of the handheld housing and comprising a cylindrical portion, a motor, and an articulation mechanism. The articulation mechanism may comprise a shaft comprising an outer tubular member and an inner tubular member disposed within the outer tubular member and coupled to the cylindrical portion of the tissue collection chamber, a drum component slidably engaged with the cylindrical portion of the tissue collection chamber and coupled to the outer tubular member, an articulation drive component rotatably coupled to the drum component and to the cylindrical portion of the tissue collection chamber, and a tissue removal assembly coupled to the shaft and operable by the motor. The shaft may be articulated by rotating the articulation drive component and causing the drum component to translate in a proximal direction.
