CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;Institut Pasteur;UNIVERSITE PARIS DESCARTES;Université Grenoble Alpes
发明人:
申请号：
EP19305479.8
公开号：
EP3722295A1
申请日:
2019.04.12
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The present invention relates to compounds of formula (A), their enantiomers and their pharmaceutically acceptable salts, as RED-SMU1 disruptors. These compounds may be useful in the treatment and/or prevention of virus infections, cancer, but also for in vitro applications. In Formula (A), U, V and W are each independently an atom chosen from C, N, O and S； R1 is a radical chosen from C1-C6-alkoxy, -NO2, -NH2, -COOH, halogen and -O-CH2-CH2-COOH； n is an integer comprised between 1 and 3； R2 may be present or absent, and when present, is a radical chosen from -NH-CO-NH-Alk, -NH-CS-NH-Alk and -CH2-CO-NH-Alk, wherein Alk is a C1-C6 alkyl； Het is a heteroaryl which may be fused to the aromatic cycle comprising U, V and W, and which may be substituted； R3 is a radical chosen from -phenyl-triazole-aralkyl, -NH-(CH2)m-alkyne, -NH-(CH2)m-OH, -NH-(CH2)m-triazole-fluorophore and -NH-(CH2)m-triazole-heterocycle； m is an integer comprised between 1 and 5； t is equal to 0 or 1； and R4 is a radical chosen from H, halogen and -C(R5)(R6)-CH2OH, wherein R5 and R6 each represent H or a C1-C6 alkyl.
