FORMES DE SELS ET POLYMORPHES DE (R)-1-(4-(6-(2-(4-(3,3-DIFLUOROCYCLOBUTOXY)-6-METHYLPYRIDINE-2-YL) ACETAMIDO)PYRIDAZINE-3-YL)-2-FLUOROBUTYL)-N-METHYL-1H-1,2,3-TRIAZOLE-4-CARBOXAMIDE

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专利权人:

THE UNIVERSITY OF TEXAS SYSTEM;BOARD OF REGENTS

发明人:

JONES, PHILIP,SOTH, MICHAEL J.,BURKE, JASON B.,LE, KANG,LIU, GANG

申请号：

CA3009355

公开号：

CA3009355A1

申请日:

2016.12.21

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

Disclosed herein is the compound (R)-l-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6- methylpyridin-2-yl)acetamido) pyridazin-3-yl)-2-fluorobutyl)-N-methyl-lH-l,2,3-triazole-4- carboxamide, and salt forms and polymorphs thereof demonstrating improved exposure after oral dosing. Methods of inhibition GLSl activity in a human or animal subject are also provided.

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