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Compositions and methods for treating cancer and other diseases
专利权人:
Prabodhika Mallikaratchy;David A. Scheinberg
发明人:
David A. Scheinberg,Prabodhika Mallikaratchy
申请号:
US13510221
公开号:
US09045756B2
申请日:
2010.11.16
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Aptamers and improved aptamers are provided with enhanced efficacy for binding to target molecules in vivo or for treating cancer or other diseases. Such improvements in aptamers are provided that enhance in vivo efficacy such as binding to the target molecule or enhancing anti-cancer activity. Such improvements also include stability to serum nucleases, reduced binding to a soluble form of the target molecule, increased avidity, affinity or specificity to the target molecule on a cell surface, increased lifetime in circulation, or any combination of the foregoing. Improvements are provided by truncation, multimerization, including at least one non-natural nucleic acid, adding a 3′ or 5′ polyethylene glycol, or any combination thereof. Aptamers for treatment of autoimmune diseases are also provided.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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