A 13-deoxy anthracycline and a taxane can be administered to a patient simultaneously,separately, sequentially, or consecutively to produce a therapeutic anticancereffect with reduced toxicity and side effect profile, compared to the administrationof equieffectrve amounts of either compound alone. A composition or preparationof a 13-deoxy anthracyclines and a taxane for producing a potent anticancer therapeuticeffect is also provided.