Carrie L. GOOGREAU;Tariq GHAYUR;Achim MOELLER;Chung-ming HSIEH;Sahana BOSE
发明人:
Chung-ming HSIEH,Carrie L. GOOGREAU,Sahana BOSE,Achim MOELLER,Tariq GHAYUR
申请号：
US13314878
公开号：
US20120230911A1
申请日:
2011.12.08
申请国别(地区):
US
年份:
2012
代理人:
摘要：
TNF-α binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind TNF-α are provided. Binding proteins have high affinity for TNF-α and neutralize TNF-α activity. A binding protein can be a full-length antibody or a TNF-α-binding portion thereof. Methods of making and methods of using the binding proteins are also described. The TNF-α binding proteins are useful for detecting TNF-α and for inhibiting TNF-α activity, including in a human subject suffering from a disease or disorder in which TNF-α activity is detrimental.
