MAKDONALD R. Lok (CA),МАКДОНАЛЬД Р. Лок (CA),LEJTNER Brajan A. (US),ЛЕЙТНЕР Брайан А. (US),MAKDONALD R. Lok,МАКДОНАЛЬД Р. Лок,LEJTNER Brajan A.,ЛЕЙТНЕР Брайан А.
申请号：
RU2013148938
公开号：
RU0002606169C2
申请日:
2012.04.05
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
FIELD: medicine.SUBSTANCE: group of inventions relates to medicine, namely to neurology, neurosurgery and pharmacology, and can be used for therapeutic treatment of delayed state complication, wherein blood gets into subarachnoid space. Application of microdispersed composition is proposed for preparing drug for treating such conditions. Composition contains powder suspension of microparticles, containing therapeutic amount of agent, selected from group consisting of calcium channel antagonist, endothelin antagonist (ET) and antagonist of channels with transitory receptor potential (TRP), impregnated in matrix or on matrix of biopolymer, and pharmaceutical carrier, which gives viscosity to composition. Microparticles have uniform distribution of size of microparticles. Average particle size is 66 μm. Each microparticle contain at least 40 wt% of therapeutic agent. Method of treatment is also disclosed, which involves use of said microdispersed composition. Sterile set comprises microdisperse composition and syringes with suspension and pharmaceutically acceptable carrier. Method for obtaining microdispersed composition involves use of said set.EFFECT: use of inventions provides gradual release of therapeutic agent for long period of time and introduction into brain ventricle so, that therapeutic composition contacts and flows, at least one cerebral artery in subarachnoid space, not entering system of blood flow in amount, which causes undesirable side effects.23 cl, 21 dwg, 6 tbl, 1 exГруппа изобретений относится к медицине, а именно к неврологии, нейрохирургии и фармакологии, и может быть использована для терапевтического лечения отсроченного осложнения состояния, при котором кровь попадает в субарахноидальное пространство. Предложено применение микродисперсной композиции для изготовления лекарственного средства для терапевтического лечения таких состояний. Композиция содержит порошковую суспензию микрочастиц, содержащих терапевтическое количество средства, выбранн
