KIM, Hong Kee,SHIN, Ho Chul,LEE, Yoon-Jung,HONG, Seok Hyun,LEE, Kyu Ho,KIM, Hun-Teak,KWAK, Yong-Kyu
申请号：
EP15776327
公开号：
EP3130333A4
申请日:
2015.04.07
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
The present invention relates to a method for preparing polymeric microspheres to improve the drug encapsulating efficiency and, more specifically, to a method for preparing polymeric microspheres, the method comprising the steps of: preparing an internal water phase (w1) and an oil phase (0) mixing the internal water phase and the oil phase to prepare a W1/0 emulsion, followed by cooling mixing the W1/0 emulsion with an external water phase (W2) to prepare a W1/0/W2 emulsion and drying the prepared W1/0/W2 emulsion, followed by collection. The method of the present invention can increase the drug encapsulating efficiency and manufacture polymeric microspheres having high drug contents through a procedure of maintaining the step of solidifying the oil phase at a particular temperature for a particular period of time, and thus the method of the present invention is effective in the preparation of sustained release-type drugs.
