AGENTS DE LIAISON OCTAMÈRES TÉTRASPÉCIFIQUES ET ANTICORPS ANTI-TOXINE A ET ANTI-TOXINE B DE CLOSTRIDIUM DIFFICILE POUR LE TRAITEMENT DE L'INFECTION À C. DIFFICILE

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专利权人:

University of Maryland; Baltimore

发明人:

FENG, Hanping,GUAN, Yongjun,ZHANG, Yongrong,YANG, Zhiyong,SHI, Lianfa

申请号：

EP16747370

公开号：

EP3253790A4

申请日:

2016.02.05

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

Novel, antibody-based binding agents derived from human and camelid immunoglobulins are described. These binding agents recognize and bind with specificity to Clostridium difficile toxin A and/or toxin B and in some cases exhibit toxin neutralizing activity. These binding agents can be used to treat or prevent primary and recurrent CDI. The binding agents include camelid VHH peptide monomers, linked groups of VHH peptide monomers, VHH peptide monomers joined to antibody Fc domains, and VHH peptide monomers joined to IgG antibodies.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/