N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-PHENYL-BENZENESULFONAMIDES AND N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-(2-PYRIDYL)BENZENESULFONAMIDES AND THEIR THERAPEUTIC USE
Patel, Lisa,Patel, Lisa,Smith, Stephen Allan,Smith, Stephen Allan,Greig, Iain Robert,Greig, Iain Robert,Williams, Samuel Cameron,Williams, Samuel Cameron
申请号：
HRP20171611
公开号：
HRP20171611T1
申请日:
2017.10.24
申请国别(地区):
HR
年份:
2017
代理人:
摘要：
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and N-(4-hydroxy-4-methyl -cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to herein as HMC compounds) that are useful, for example, in the treatment of disorders (e.g., diseases) including, inflammation and/or joint destruction and/or bone loss disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system inflammatory and autoimmune disorders, for example, rheumatoid arthritis psoriasis psoriatic arthritis chronic obstructive pulmonary disease (COPD) asthma atherosclerosis inflammatory bowel disease ankylosing spondylitis multiple sclerosis systemic lupus erythematosus Sjogrens syndrome a disorder associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, or Pagets disease cancer, such as a haematological malignancy, such as multiple myeloma, leukemia, or lymphoma, or a solid tumour cancer, such as bladder cancer, breast cancer (female and/or male), colon cancer, renal cell carcinoma, kidney cancer, lung cancer, pancreatic cancer, gastric cancer, prostate cancer, brain cancer, skin cancer, thyroid cancer, basal cell ameloblastoma, or melanoma a disorder associated with fibrosis, such as systemic sclerosis or scleroderma or a rare vasculitide, such as Behçets disease. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, for example, in therapy.
