Heteroaromatics and its purposes as dopamine D 1 ligand农业专利-农业学术服务平台

发明人:: M．A．布罗德尼,M．A．布羅德尼,J．E．达沃伦,J．E．達沃倫,A．B．杜内,A．B．杜內,I．V．叶夫列莫夫,I．V．葉夫列莫夫,D．L．F．格雷,M．E．格林,J．L．亨德森,C．李,S．R．门特,S．R．門特,S．V．奥尼尔,S．V．奧尼爾,B．N．罗杰斯,B．N．羅杰斯,张磊,張磊,M.A.布罗德尼,M.A.布羅德尼,J.E.达沃伦,J.E.達沃倫,A.B.杜内,A.B.杜內,I.V.叶夫列莫夫,I.V.葉夫列莫夫,D.L.F.格雷,M.E.格林,J.L.亨德森,C.李,S.R.门特,S.R.門特,S.V.奥尼尔,S.V.奧尼爾,B.N.罗杰斯,B.N.羅杰斯

摘要：: The present invention partly provides the compound and its pharmaceutically acceptable salt of Formulas I； Preparation method and prepare intermediate； With the composition comprising this kind of compound or salt； And its purposes in (or D1- is relevant) obstacle that treatment D1- is mediated, the obstacle includes, such as schizophrenia (such as its cognition and negative symptoms), cognitive impairment (such as cognitive impairment relevant to schizophrenia, AD, PD or medicinal treatment), age-related cognitive decline, dementia and Parkinson's disease.本發明部分地提供式I的化合物及其藥學上可接受的鹽；其製備方法和製備中間體；和包含這類化合物或鹽的組合物；及其在治療D1-介導的(或D1-相關的)障礙中的用途，所述障礙包括，例如精神分裂症(例如其認知和陰性症狀)、認知缺損(例如與精神分裂症、AD、PD或藥物療法相關的相關的認知缺損)、與年齡相關的認知衰退、癡呆和帕金森氏病。