An orthopedic plate system comprises a plurality of fasteners such as pegs or screws and a plate having two sets of holes for the fasteners. The first set of at least one hole includes internal threads that receive a fastener having a head which includes external threads that mate with the internal threads of the hole to lock the fastener at a fixed angle relative to the plate. The second set of at least one hole is devoid of internal threads and has a concavely rounded internal surface and which receives a convexly rounded external surface of a locking insert, which receives a variable axis fastener. The variable axis fastener causes the locking insert to expand to lock the variable axis fastener at a selected angle relative to the plate.