Device (10) for gripping and positioning prosthesis parts, comprising: a gripping head (27) provided with one or more air passage channels (29) and configured to be inserted inside a seating (28) of a prosthesis part (11); a depressor unit (19) selectively drivable to determine a condition of depression or vacuum that is transmitted to the channels (29) of the gripping head (27) so that the head (27) securely holds the prosthesis part (11).