It includes treating hypochondriacal pharmaceutical composition with what using Radix Glycyrrhizae, jujube as made of raw material that the present invention, which discloses one group,. The present invention also discloses the preparation methods in relation to aforementioned pharmaceutical compositions. It is demonstrated experimentally that pharmaceutical composition of the present invention can obviously reduce the temperature decline that test mice hangs tail dead time and reserpine induction, so as to confirm that pharmaceutical composition of the present invention has effects that anti-melancholy.本發明公開一組包括以甘草、大棗為原料製成的用於治療憂鬱症的藥物組合物。本發明同時還公開有關上述藥物組合物的製備方法。實驗證明,本發明藥物組合物可明顯減少受試小鼠懸尾不動時間和利血平誘導的體溫下降,從而可以證實本發明藥物組合物具有抗憂鬱的功效。