PROBLEM TO BE SOLVED: To provide a biological adhesive composition capable of suppressing pain during peeling after use without peeling for long time during attachment and a biological adhesive sheet having an adhesive layer derived from the biological adhesive composition.SOLUTION: There is provided a biological adhesive composition containing a constitutional unit (A) derived from a (meth)acrylic monomer with solubility parameter of 9.5 or less of 30 mass% to 65 mass% based on the total constitutional units and a constitutional unit (B) derived from a (meth)acrylic monomer with solubility parameter of over 9.5 of 35 mass% or more based on total constitutional units and a surfactant.SELECTED DRAWING: None【課題】貼付中に長時間剥離せず、かつ使用後の剥離時の痛みを抑制できる生体用粘着剤組成物および生体用粘着剤組成物に由来する粘着剤層を有する生体用粘着シートを提供すること。【解決手段】溶解パラメータが９．５以下の（メタ）アクリル系単量体に由来する構成単位（Ａ）を全構成単位に対して３０質量％以上６５質量％以下含み、かつ溶解パラメータが９．５を超える（メタ）アクリル系単量体に由来する構成単位（Ｂ）を全構成単位に対して３５質量％以上含む（メタ）アクリル系重合体と、界面活性剤とを含有する生体用粘着剤組成物。【選択図】なし
