Ken McDonald;Pat O'Flynn;Mark Ledwidge;John Gilmer
发明人:
John Gilmer,Mark Ledwidge,Ken McDonald,Pat O'Flynn,Pat OFlynn
申请号：
US13992663
公开号：
US09566342B2
申请日:
2011.12.08
申请国别(地区):
US
年份:
2017
代理人:
摘要：
A combination of: a first tetracycline (TC) component； and a second component capable of releasing nitric oxide (NO) or a nitrate capable of mimicking NO effects in vivo (NO mimetic). The combinations of the invention advantageously act as more effective MMP modulators with selective reductions in circulating MMP-9 levels in-vivo and inhibitory effects on MMP-2 and MMP-9 levels in-vitro. The combinations of the invention also advantageously act as modulators of inflammation mediators. The co-existence of abnormalities of MMP enzymes and inflammation in many diseases make these characteristics advantageous. Therefore, the various combinations of the invention find utility in medical applications where MMPs and/or inflammation is implicated.
