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PRÉPARATION À LIBÉRATION PROLONGÉE DE MOSAPRIDE POUR FOURNIR DES EFFETS CLINIQUES PHARMACOLOGIQUES AVEC UNE ADMINISTRATION UNE FOIS PAR JOUR
专利权人:
KOREA UNITED PHARM. INC.
发明人:
KIM, BYUNG JIN,CHOI, YOUN WOONG,SONG, HEE YONG,KIM, JONG-IL,KIM, YONG HEE,LIM, MYOUNG-HWA,KIM, MIN SOO,HA, DAE-CHUL
申请号:
EP14764801
公开号:
EP2974720A4
申请日:
2014.03.14
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
The formulation for oral administration of the present invention containing Mosapride or its salt is a double layer formulation consisting of a fast-release layer for rapid release of a drug and a sustained-release layer for slow release in order to simultaneously satisfy the rapid exhibition of pharmacological activities and sustained maintenance of pharmacological activities for 24 hours, wherein the high-viscosity hydroxypropyl methylcellulose (HPMC) and the low-viscosity HPMC are used in mixture such that the content of a high viscosity HPMC as a controlled-release matrix within the sustained-release layer has a higher content, thereby capable of controlling the dissolution rate in the regions having different pH values within the gastrointestinal tract and/or the retention time in the gastrointestinal tract. Additionally, the formulation of the present invention is a small-sized preparation with a total weight of 200 mg or less, preferably from 150 mg to 160 mg, thus capable of improving drug compliance of patients.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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