A tablet dispenser for dispensing randomly stored tablets from a bottle is disclosed. The dispenser includes offset inlet and outlet paths, a helical dispensing screw, and a rotation drive. The inlet path can be positioned for receiving a tablet to be dispensed from a bottle or other supply of tablets. The outlet path can be positioned for dispensing a tablet. The helical dispensing screw can be configured to rotate, driven by the rotation drive, to transport a tablet from the inlet path to the outlet path. The rotation drive can be operable by pushing the structure defining the inlet path and the outlet portion toward each other. The dispenser can be equipped with a dispensing sensor and memory that records data regarding each pill dispensed, such as the time of dispensing and the number of pills remaining, and optionally transmits the data to a device on or off the patient's premises.