SINGLE-CHAIN MULTIVALENT BINDING PROTEINS WITH EFFECTOR FUNCTION

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专利权人:

EMERGENT PRODUCT DEVELOPMENT SEATTLE; LLC

发明人:

SCHULER, ALWIN,THOMPSON, PETER, ARMSTRONG,LEDBETTER, JEFFREY, A,HAYDEN-LEDBETTER, MARTHA, SUSAN,GROSMAIRE, LAURA, SUE,BADER, ROBERT,BRADY, WILLIAM,TCHISTIAKOVA, LIOUDMILA,FOLLETTIE, MAXIMILLIAN, T,CAL

申请号：

NZ59686507

公开号：

NZ596865A

申请日:

2007.06.12

申请国别(地区):

NZ

年份:

2013

代理人:

摘要：

Disclosed is a single-chain protein comprising from amino to carboxy terminus: (a) a first binding domain derived from an immunoglobulin-like molecule or the variable regions of an immunoglobulin (b) a Fc region comprising a domain derived from an immunoglobulin CH2 domain, wherein said Fc region does not comprise a domain derived from an immunoglobulin domain (c) a linker peptide of at least 5 amino acids and (d) a second binding domain derived from an immunoglobulin-like molecule or the variable regions of an immuno globulin, wherein the first or second binding domain binds CD3.

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