The George Washington University;The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人:
Wenge ZHU,Wei ZHOU,Wei ZHENG,Wei SUN
申请号：
US16500959
公开号：
US20200031920A1
申请日:
2018.04.04
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure provides methods, pharmaceutical compositions, dosing regimens, and kits comprising a DNA damaging agent and an inhibitor of the Janus kinase 2-signal transducer and activator of transcription 5 (JAK2-STAT5) pathway, including methods of inhibiting the JAK2-STAT5 pathway in a cell, methods of treating cancer in a subject, and methods of decreasing or reversing resistance to a DNA damaging agent in a subject.
