PRASAD, Brinda,MURPHY, Andrew,MEAGHER, Karolina,MASON, Peter
申请号：
SG11202001160X
公开号：
SG11202001160XA
申请日:
2018.09.27
申请国别(地区):
SG
年份:
2020
代理人:
摘要：
According to certain embodiments, the present disclosure provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds a Staphylococcus species target antigen and a second antigen binding domain that binds a complement component. In certain embodiments, the bispecific antigen-binding molecules of the present disclosure are capable of binding to the Staphylococcus species target antigen with an EC50 of about 10 nM or less, and/or are capable of promoting complement deposition on the Staphylococcus species with an EC50 of about 10 nM. The antibodies of the disclosure are useful for treating diseases in which inhibition or reduction of the growth of a Staphylococcus species is desired and/or therapeutically beneficial, for example, for treating staphylococcal infections including a skin infection, cellulitis, pneumonia, meningitis, urinary tract infection, toxic shock syndrome, endocarditis, osteomyelitis, bacteremia, or sepsis, or for preventing or treating a staphylococcus infection that occurs as a result of a surgical procedure.
