LI Dzae Kvang,ЛИ Дзае Кванг,OKH Dzun Taek,ОХ Дзун Таек,LI Dzae Von,ЛИ Дзае Вон,LI Seo Khi,ЛИ Сео Хи,KIM Il-Khiang,КИМ Ил-Хианг,LI Dzae Joung,ЛИ Дзае Йоунг,BAE Su Jeal,БАЕ Су Йеал,LI Se Ra,ЛИ Се Ра,KIM
申请号：
RU2015135369
公开号：
RU0002627361C2
申请日:
2014.01.29
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
FIELD: pharmacology.SUBSTANCE: invention relates to a biaryl or heterocyclic biaryl-substituted cyclohexene derivatives of formula I a stereoisomer thereof or a pharmaceutically acceptable salt thereof, wherein R1 is -H or -C1-C3 alkyl R2 is -C1-C3alkyl each of R3, R4, R5 and R6 is independently -H, halogen, -NO2 , -C1-C3alkyl or -OC1-C3alkyl R7 is -H, -(C=O)OR8 or -C(O)-NR11R12 R8 R8 is -H or -C1-C3alkyl R11 and R12 are each independently -H or -C1-C3alkyl or can form a 4 to 6-member non-aromatic ring, wherein the non-aromatic ring may contain a N heteroatom and 0 to 1 O heteroatom, and one or more -H in the non-aromatic ring may be replaced by halogen or -OH each of A1, A2 and A3 is independently N or CR9, where, if A2 or A3 is N, A1 is CR9 R9 is -H, halogen, -C1-C3alkyl or -OC1-C3alkyl B is N or CR10 R10 is -H, halogen, -OC1-C3alkyl or -(C=O)OR8 provided that one or more H atoms in -C1-C3alkyl or -OC1-C3alkyl can be substituted with -F or -CH3, and if R7 is -H, B is CR10 and R10 is -(C=O)OR8, and if R7 is not -H, R10 not -(C=O)OR8. The invention relates to a pharmaceutical composition having a CETP inhibitory activity comprising, as an active ingredient, a compound of formula I, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The compounds of the invention are intended to prevent or treat dyslipidemia or diseases associated with dyslipidemia, including angina pectoris, myocardial infarction or arteriosclerosis.EFFECT: biaryl- or heterocyclic biaryl-substituted derivatives of cyclohexene as CETP inhibitors.11 cl, 32 tbl, 172 exИзобретение относится к биарил- или гетероциклическим биарилзамещенным производным циклогексена формулы I, его стереоизомеру или его фармацевтически приемлемой соли, где R1 представляет собой -Н или -C1-С3алкил R2 представляет собой -C1-С3алкил каждый из R3, R4, R5 и R6 представляет собой независимо -Н, галоген, -NO2, -C1-С3алкил или -OC1-С3алкил R7 представляет собой -Н,
