The invention discloses the pharmaceutical composition that treatment mammal includes people's diabetes B, especially contain (3aS,5s,6aR) -5- (2- (the fluoro- pyrrolidin-1-yls of (2S, 4S) -2- cyano -4-) -2- oxygen ethylamino)-N,N,The pharmaceutical composition of the fixed dosage of 5- trimethyls-hexahydro ring penta [C] pyrroles -2 (1H)-carbamyl or its pharmaceutically acceptable salt and melbine or its pharmaceutically acceptable salt (such as hydrochloride) combination, the method and described pharmaceutical composition treatment mammal that prepare described pharmaceutical composition include the purposes of people's diabetes B.本發明公開了治療哺乳動物包括人2型糖尿病的藥物組合物，特別是含有(3aS,5s,6aR)-5-(2-((2S，4S)-2-氰基-4-氟-吡咯烷-1-基)-2-氧乙氨基)-N,N,5-三甲基-六氫環戊[C]吡咯-2(1H)-氨甲酰或其藥學上可接受的鹽和二甲雙胍或其藥學上可接受的鹽（如鹽酸鹽）的固定劑量組合的藥物組合物，製備所述藥物組合物的方法和所述藥物組合物治療哺乳動物包括人2型糖尿病的用途。
