Methods of treating lymphoma and rheumatoid arthritis with cyclopentyl (2S)-cyclohexyl[({6-[3-(hydroxyamino)-3-oxopropyl]pyridin-3-yl}methyl)amino]acetate
GlaxoSmithKline Intellectual Property Development Limited
发明人:
Alan Hornsby Davidson,David Festus Charles Moffat,Francesca Ann Day,Alastair David Graham Donald
申请号：
US14324510
公开号：
US09273003B2
申请日:
2014.07.07
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Compounds of formula (I) inhibit HDAC activity:wherein A, B and D independently represent ═C— or ═N—； W is a divalent radical —CH═CH— or CH2CH2—； R1 is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular carboxyesterase enzymes to a carboxylic acid group； R2 is the side chain of a natural or non-natural alpha amino acid； z is 0 or 1； and Y, L1, and X1 are as defined in the claims.
