Antimicrobial films are disclosed herein. The antimicrobial films are configured for application to surfaces, particularly to surfaces with which humans and animals come into contact. The antimicrobial films include a substrate layer and an antimicrobial layer. The substrate layer is generally a polymer, such as polyethylene. The antimicrobial layer is generally a composition of an antimicrobially-active ingredient dispersed in a dispersant. Typical dispersants include aqueous-based or solvent-based components (e.g., inks, primers, or varnishes). Antimicrobial films, as described herein, may be affixed to surfaces using an adhesive. Alternatively, the antimicrobial films may be applied to a surface using a heat-shrink process.