A compound of formula (VII): ** ** Formula or a pharmaceutically acceptable salt thereof, wherein: stereochemical configurations described asterisked positions indicate relative stereochemistry Q is> = N- or> = C (Rk) - X is -CH2-, -CHF-, -CH2-, -NH- or -O- Y is -O-, -S- or -C (Rm) (Rn) - Ra is selected from the group consisting of hydrogen, fluoro, -OH, -OCH 3 and -CH 3 or Ra and Rc together form a bond R is selected from the group consisting of hydrogen, fluoro, C1-4 aliphatic, and C1-4 fluoroaliphatic R is selected from the group consisting of hydrogen, fluoro and -OR 5 or Ra and Rc together form a bond Rd is selected from the group consisting of hydrogen, fluoro, C1-4 aliphatic, and C1-4 fluoroaliphatic Re is hydrogen or C1-4 aliphatic each Rf is independently hydrogen or C1-4 aliphatic and each Rh is independently hydrogen, halo, -CN-, -OR5, -N (R4) 2, -SR6 or opcionalmentesustituido C1-4 aliphatic group Rj is hydrogen, -OR 5, -SR 6, -N (R4) 2 or an aliphatic, aryl or heteroaryl, optionally substituted R k is hydrogen, halo, -OR 5, -SR 6, -N (R4) 2 or a C1-4 aliphatic group optionally substituted m is hydrogen, fluoro, -N (R4 ) 2 or a C1-4 aliphatic group optionally substituted Rn is hydrogen, fluoro or a C1-4 aliphatic group optionally substituted ORM and Rn together form> = O or> = C (R5) 2 each R4 is independently hydrogen aliphatic, aryl, heteroaryl or heterocyclyl, opcionalmentesustituido or two R4 on the same nitrogen atom, together with the nitrogen atom, form a ring heterociclilode 4 to 8 atoms optionally substituted, which also has the nitrogen atom, 0-2 ring heteroatoms independently anilloseleccionados from N, O and S and each R5 is independently hydrogen or an aliphatic, aryl, heteroaryl or heterocyclyl, opcionalmentesustituido each R6 is independently an aliphatic, aryl or heteroaryl, optionally substituted m is 1, 2 or 3 V2 is -N (R8) -, -O- or -S- R8 is hydrogen or C1-4 aliphatic ring D is an aryl or cycloaliphatic ring, heteroaryl, heterocyclyl,
