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Process for preparing biphenyl imidazole compounds
专利权人:
THERAVANCE INC.
发明人:
ZHANG WEIJIANG,COLSON PIERRE-JEAN,FASS TIMOTHY
申请号:
NZ59827810
公开号:
NZ598278A
申请日:
2010.09.28
申请国别(地区):
NZ
年份:
2014
代理人:
摘要:
598278 Provided are processes for preparing intermediates of formula (I), (II) and (III) where R1, R2, R3, R4 and P are as defined in the specification, useful for preparing compounds of the formula (IV) where R1, R2 and R3 are as defined in the specification. Further provided are crystalline 4&rsquo-(5-aminomethyl-2-ethoxy-4-ethylimidazol-1-ylmethyl)-3&rsquo-fluorobiphenyl-2-carboxylic acid t-butyl ester, crystalline 4&rsquo-{ 5-[((S)-2-acetylsulfanyl-4-methylpentanoylamino)methyl]-2-ethoxy-4-ethylimidazol-1-ylmethyl} -3&rsquo-fluorobiphenyl-2-carboxylic acid and a compound of formula (3) where R1, R2 and P are as defined in the specification. Further provided are compounds of formula (I), (II), (III) when prepared by the processes described.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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