The present invention relates to phosphorus-containing prodrug of formula I:wherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts and prodrugs thereof, for effectively delivering biologically active phosphonates including nucleoside phosphonates and nucleoside monophosphates in biological system. The present invention also relates to the therapeutic uses of compound of formula I.本發明係關於式I之含磷前藥及其醫藥上可接受的鹽類及前藥:其中各符號如說明書中之定義,用以有效地輸送生物上活性的膦酸酯,包括核苷膦酸酯及核苷單磷酸酯進入生物系統。本發明亦關於式I化合物之治療用途。
