Sarah J. HATSELL,Aris N. ECONOMIDES,Christopher SCHOENHERR,Vincent J. IDONE
申请号：
US16439068
公开号：
US20190380315A1
申请日:
2019.06.12
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A genetically modified rodent is provided that comprises a modified Acvr1 gene that comprises a conditional altered exon 7 encoding R258G in anti sense orientation, flanked by site-specific recombinase recognition sites, wherein the altered exon is inverted to sense orientation upon action of a recombinase, resulting in ectopic bone formation.
