A remote ischemic preconditioning application device may include a first compression portion that is operable to apply a coil shaped pressure pattern around at least 360 degrees of an upper arm portion and a second compression portion that is selectively operable to apply a coil shaped pressure pattern around at least 360 degrees of a lower arm portion. The device may use remote ischemic preconditioning to: reduce blood flow in the upper and lower arm portions for at least 30 continuous minutes; and 2) increase blood flow in the patient as a result of remote ischemic preconditioning.