Systems and methods to acquire first two-dimensional projection images of a patient volume using first imaging parameters, acquire second two-dimensional projection images of the patient volume acquired using second imaging parameters, generate, using a first image reconstruction technique, a first three-dimensional image based on the first two-dimensional projection images, receive one or more indications of features of the patient volume identified by an operator in the first three-dimensional image, generate, using a second image reconstruction technique, a second three-dimensional image based on the second two-dimensional projection images, perform automated feature extraction on the second three-dimensional image to automatically extract information associated with features of the patient volume, and generate a feature report of the patient volume based on the one or more indications of features and the information associated with features.
