Hyperbaric chamber control system and apparatus and related methods. A system for controlling, measuring, and reporting hyperbaric chamber sessions using the partial pressure of oxygen as the lead variable. Air is gently flushed from the bottom of the chamber, upwards, and a nostril-level oxygen pickup measures oxygen concentration in the chamber. Chamber pressure and oxygen concentration values are used to calculate the partial pressure of oxygen, and the session time is adjusted so that a subject treatment accurately reflects prescribed treatment.