Monoclonal antibody capable of inhibiting the dimerization of the receptor for hepatocyte growth factor (c-met)； that the isolated Nucleic Acid Coding； vector and host cell that include； Process for the production of Antibody, the Antibody used to treat cancer (Divisional The application of 1296 - 11).
The disclosure relates to an antibody capable of binding specifically to the human c-Met receptor and/or capable of specifically inhibiting the tyrosine kinase activity of said receptor, with an improved antagonistic activity, said antibody comprising a modified hinge region. The disclosure also relates to a composition comprising such an antibody antagonist to c-Met and its use as a medicament for treating cancer.La invención se refiere a un anticuerpo novedoso capaz de unirse específicamente al receptor c-Met humano y/o capaz de inhibir específicamente la actividad de tirosina quinasa de dicho receptor, con una actividad antagonista mejorada, comprendiendo dicho anticuerpo una región bisagra modificada. La invención se refiere además a una composición que comprende ese tipo de anticuerpo antagonista de c-Met y su uso como medicamento para tratar el cáncer.
