Formula (i), (ii) or (iii) (in formula (i), as for R1 and R2 alkyl group and the like showing As for R3, R4, and R5 hydrogen atom and the like showing Ar shows the phenyl group and the like. In formula (ii), as for R11, R12, R13, R14, R15, R16, and R17 in the respective independence hydrogen atom and the like showing X shows the phosphorus atom and the like. In formula (iii), as for R21, R22, and R23 in respective independence hydrogen atom and the like showing R24 and R25 show the C3 6 alkyl group and the like) with the chemical compound which is displayed or to include that salt and the like in the respective independence, the inhibiter for useful histone methylation enzyme Pr Set7 prevention of the cancer and the life habit illness and/or as a active ingredient of the medicine for remedying.式(I)、(II)、又は(III)〔式(I)中、R1及びR2はアルキル基等を示し;R3、R4、及びR5は水素原子等を示し;Arはフェニル基等を示す。式(II)中、R11、R12、R13、R14、R15、R16、及びR17はそれぞれ独立に水素原子等を示し;Xはリン原子等を示す。式(III)中、R21、R22、及びR23はそれぞれ独立に水素原子等を示し;R24及びR25はそれぞれ独立にC3-6アルキル基等を示す〕で表される化合物又はその塩などを含み、がんや生活習慣病の予防及び/又は治療のための医薬の有効成分として有用なヒストンメチル化酵素Pr-Set7に対する阻害剤。
