The Board of Trustees of the Leland Stanford Junior University
发明人:
Karl A. Deisseroth,Viviana Gradinaru
申请号：
US16151057
公开号：
US20190257724A1
申请日:
2018.10.03
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Compositions and methods are provided for TEMPEST (Target-Element Modification by Physical and Enduring Structural Transmutation), a method for creating durable structures in vivo in a cell-type and/or circuit specific manner via the use of insoluble polymers. TEMPEST provides a way to functionally remove cells while preserving their “shadow” for easy post-experiment detection and classification. The method of the invention are of particular interest for modifying neurons, which may be central nervous system or peripheral nervous system cells, however the approach may be applied to other cellular systems as well, either in culture system models or in animals.
