ELLIS-BEHNKE, RUTLEDGE,NORCHI, TERRENCE W.,KELLY, STEPHEN RICHARD
申请号：
CA2722465
公开号：
CA2722465C
申请日:
2008.04.25
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
A method has been developed of preventing or limiting formation of adhesionsby administering to a site in needthereof, in the absence of or after bleeding or leakage of fluid has beensubstantially stopped, a self- assembling material which formsa barrier to formation of adhesions. In one embodiment, the self-assemblingmaterial comprises peptides having a sequence of aminoacid residues conforming to one or more of Formulas I- IV: ((Xaa neuXaa+)x(Xaa neu -Xaa-)y)n (I) ((Xaa neu -Xaa )x(Xaa neu -Xaa+)y)n(II)((Xaa + -Xaa neu)x(Xaa - -X aa neu)y)n (III)((Xaa - -Xaa neu)x(Xaa + -X aaneu)y)n (IV) wherein Xaa neu represents an amino acid residuehaving a neutral charge； Xaa + represents an amino acid residue having apositive charge； Xaa - represents an amino acid residuehaving a negative charge； x and y are integers having a value of 1, 2, 3, or4, independently； and n is an integer having a value of1-5. In another embodiment, the self-assembling materials are peptidomimetics,nucleotidomimetics, di- and triblock copolymers,N- alkylacrylamides, or dendimers. These materials are also useful in a methodfor regeneration or repair of tissue or cells formingtissue
