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Companion diagnostic for anti-hyaluronan agent therapy and methods of use thereof
专利权人:
HALOZYME INC.
发明人:
JIANG PING,SHEPARD H. MICHAEL,HUANG LEI
申请号:
NZ62448912
公开号:
NZ624489A
申请日:
2012.10.24
申请国别(地区):
NZ
年份:
2016
代理人:
摘要:
Disclosed is a TSG-6-link module (LM) multimer, comprising: - a first polypeptide containing a TSG-6-LM linked directly or indirectly via a linker to a first multimerisation domain and - a second polypeptide containing a TSG-6-LM linked directly or indirectly via a linker to a second multimerisation domain, wherein: - the first and second multimerisation domains each comprise a sequence of amino acids, whereby the first and second polypeptides form a multimer and - the TSG-6-LM multimer has a binding affinity to hyaluronan (HA) with an association constant of at least 10^7 M^-1.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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